c-ANCA induce neutrophil-mediated lung injury a model of acute Wegener ́s Granulomatosis Short title: Anti-PR3-antibodies mediate acute lung injury
نویسندگان
چکیده
Katja Hattar, Stefanie Oppermann, Christiane Ankele, Norbert Weissmann, Ralph Theo Schermuly, Rainer Maria Bohle, Regina Moritz, Bettina Krögel, Werner Seeger, Friedrich Grimminger, Ulf Sibelius and Ulrich Grandel 1 Medical Clinic V, University of Giessen Lung Center (UGLC), Giessen, Germany. 2 Medical Clinic II, University of Giessen Lung Center (UGLC), Giessen, Germany. 3 Department of Pathology, University of Saarland, Homburg-Saar, Germany. 4 Mayo Clinic , Department of Physiology and Biomedical Engineering, Rochester, USA
منابع مشابه
c-ANCA-induced neutrophil-mediated lung injury: a model of acute Wegener's granulomatosis.
Anti-neutrophil cytoplasmic antibodies (c-ANCA) targeting proteinase 3 (PR3) are implicated in the pathogenesis of Wegener's granulomatosis (WG). Fulminant disease can present as acute lung injury (ALI). In this study, a model of ALI in WG was developed using isolated rat lungs. Isolated human polymorphonuclear leukocytes (PMNs) were primed with tumour necrosis factor (TNF) to induce surface ex...
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Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). Progress in study of these antibodies in rodents has been hampered by lack of PR3 expression on murine neutrophils, and by different Fc-receptor affinities for IgG across species. Therefore, we tested...
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Recently it has been reported, that immunoglobulin Y (IgY) can be used instead of polyclonal antibodies extracted from mammals (IgG) for the purpose of diagnosis and therapy. These antibodies are found to have better properties in terms of specificity and ease of large-scale production. In addition, IgY binds neither to mammalian complement or Fc-receptors nor does it interfere with rheumatoid ...
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Anti-neutrophil cytoplasmic antibodies (ANCA) targeting proteinase 3 (PR3) possess a high sensitivity and specificity for Wegener's granulomatosis. Due to their capacity of directly activating neutrophils, a pathogenetic role for these autoantibodies has been proposed. We investigated the impact of subthreshold concentrations of monoclonal anti-PR3 antibodies (anti-PR3; 0.1 microg/mL) on neutro...
متن کاملCulture-negative subacute bacterial endocarditis masquerades as granulomatosis with polyangiitis (Wegener’s granulomatosis) involving both the kidney and lung
BACKGROUND Subacute bacterial endocarditis (SBE) occasionally exhibits positive cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA) of the anti-proteinase-3 (PR-3) type. Clinically, it mimics ANCA-associated vasculitis, such as Wegener's disease with glomerulonephritis. Lung abscesses are the most common manifestation of lung involvement. We herein report a case of culture-negative SBE st...
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